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1 Introduction Male infertility is a significant global health concern, affecting approximately 8-12% of couples of childbearing age ( Male infertility specifically refers to any condition in which a males reproductive system impairs the ability to achieve a successful pregnancy

It highlights the complex interactions connecting microbial dysbiosis, disrupted gut barrier integrity, systemic inflammation, and neuroinflammation that collectively drive AD pathogenesis

Provenance and peer review Not commissioned, externally peer reviewed

doi: 10.1016/j.biopha.2018.05.003 119 WangJZhangYCaoJWangYAnwarNZhangZet al

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