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P.AchariG.SlobodnikJ

Isaac C-RJ, Ignacio V-F, Francisco G-LR, Fernando T-VJ, David P-MJ, Walfred R-F, Alberto G-IJ

ACS Appl Mater Interfaces 13:4945349461

Glutathione stabilizes the inner mitochondrial membrane, squelches reactive oxygen species (ROS) generated by mitochondrial respiration, and maintains mitochondrial DNA fidelity to profoundly influence mitochondrial function and cell survival

Cagrilintide was specifically engineered with molecular modifications to resist rapid breakdown in the body and bind effectively to amylin 1 and 3 (AMY1R, AMY3R) receptors in the brain, allowing for a more stable, once-weekly dosing regimen compared to the multiple daily injections required for older amylin analogues like pramlintide