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More than 400 mutations have been identified, most being missense mutations

Prespecified and non-prespecified exploratory analyses The prespecified subgroup analyses revealed that N -acetylcysteine was associated with a significant reduction in the annual rate of total exacerbations and moderate or severe exacerbations among patients with mMRC score 10 mg/d), or long-term use of antibiotics

M.IgarashiK.et al (2009)

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