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Hippocampal biopsies showed that individuals with major depression reveal lower levels of BDNF and its receptor TrkB, and long-term use of antidepressants promotes increased BDNF levels (111)

The development of metabolic diseases such as obesity, diabetes, and cardiovascular diseases is also affected mainly by oxidative stress

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Propionyl-CoA carboxylase functions as a heterododecameric enzyme (subunit composition: 6 6 ) and the two different subunits are encoded by the PCCA and PCCB genes, respectively