Another mechanism by which statins may contribute to ferroptosis is inhibition of the selenoprotein enzyme GPX4, limiting selenocysteine production (Stockwell et al., 2017
The efficacy of biotherapeutic agents is higher than that of conventional methods, but there are still some side effects, such as instability, low bioavailability, high rate of infection, in particular lymphomas [26]
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As reported in a randomized controlled trial, two patients with advanced liver disease, out of 69 patients in the simvastatin group, receiving simvastatin 40 mg/day experienced rhabdomyolysis, with no such sign found in the placebo group (Abraldes et al., 2016)