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[37] Neuroplasticity within the brain's reward system occurs as a result of long-term nicotine use, leading to nicotine dependence

For the peer selection and peer influence effects, we have also highlighted which results would have attained statistical significance after using the HolmBonferroni procedure to adjust the p -values for multiple testing ( p 0.025 for Fishers tests, p 0.05 for heterogeneity tests across schools or subgroups) (Holm, 1979)

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