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Regulatory peptides , 160 (1-3), 2632

Although PSC occurs in a relatively small percentage of patients with UC (2.4%-7.5%), a large percentage of patients with PSC (75%) typically have UC

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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

Despite significant advancements, there are many unanswered questions about the pathophysiological mechanisms of symptoms in high-altitude illness, and several existing mechanisms are still a matter of debate