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The Importance of FIH Trials in Clinical Development First-in-Human trials provide the first opportunity to translate preclinical evidence into early clinical knowledge

These mechanical forces are triggered by contraction of the ciliary muscle and pulsatile forces due to changes in IOP and blood pressure (Smith et al., 2007) that can be detected by specific cell surface receptors, thus enabling the cells in the TM/SC to change their biological functions in response to mechanical and pulsatile forces

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