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Boisen IM, Bllehuus Hansen L, Mortensen LJ, Lanske B, Juul A, Blomberg Jensen M

Randomized controlled trials (RCTs) report that IF reduces androgen markers, including total testosterone and free androgen index, in premenopausal females with obesity, while producing modest declines in testosterone among lean males without significantly affecting LH secretion [55]

& Schwarz, T

To date, no human clinical trials have been completed, and all published efficacy data come from controlled murine studies using intraperitoneal injection

in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )