Due to the exhaustion of cellular and extracellular GSH caused by numerous GSH-consuming pathways the severe inflammation and oxidative stress triggered by the viral infection steals GSH from crucial functions like NO-dependent vasodilatation, disallowing the patient of being protected from an inflammation that can become fatal
The last category includes malondialdehyde, oxidised lipoproteins, nitrosamines, hexanoyl-lysine, nitro-tryptophane, 8-deoxyguanosine, thymidine glycol and others, as reviewed previously [45,46,47,48,49,50,51,52,53]
[DOI] [PubMed] [Google Scholar] 59.Ferrante K.L., Shefner J., Zhang H., Betensky R., OBrien M., Yu H., Fantasia M., Taft J., Beal M.F., Traynor B., et al
Western blot analysis also showed that the accumulation of synaptophysin was long lasting (30 days), suggesting that the transportation of synaptic vesicles may be disrupted (Shojo and Kibayashi, 2006)
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