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All references to observed effects are strictly for educational and research purposes within appropriately controlled settings

This hypothesis is supported by the data that Fas-mediated cell death in mature erythrocytes can be triggered by internal stimuli like ROS and p38 MAPK signaling [194,195,196]

when lipid peroxides accumulate excessively, polyunsaturated fatty acids in hepatocytes are synthesized into easily oxidizable phospholipids under enzymatic action, which then undergo peroxidation catalyzed by enzymes, disrupting cell membrane structure and ultimately leading to hepatocyte necrosis and liver failure [58]

However, several fundamental gaps remain

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