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Finally, ROS are generated after exposure to physical agents (ultraviolet rays and heat) and after chemotherapy and radiotherapy in cancer

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Moreover, intracellular lipid accumulation or supplementation with exogenous fatty acids can trigger the generation of reactive oxygen species (ROS) and the secretion of immunosuppressive cytokines, thereby facilitating the polarization of macrophages toward a pro-tumorigenic M2 phenotype, which in turn enhances tumor cell invasiveness and metastatic potential (87)

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