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Caffeine is an example of this defense strategy and has evolved as a metabolite that is toxic and undesirable to insects, thus acting as the plants own insecticide

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Among the participants who had tried a nicotine product, 51.3% of those who reported trying Juul had vaped with the device over the last 30 days, 28.6% of those who reported trying a cigarette had smoked one within the last 30 days, and 28.7% of those who reported trying a nonpod-based e-cigarette had used such a device over the last 30 days