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Curr Med Chem 22(4):438464 Kalgutkar AS et al (2008) Toxicophores, reactive metabolites and drug safety: when is it a cause for concern

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Furthermore, this kinase cascade enhances the transcriptional activity of HIF-1 by binding the TAD sequence of HIF-1 through the transcriptional co-activators p300/CBP ( Figure 3C )

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This is the second piece of the puzzle