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As a result, a titrated oxygen regimen is recommended for the management of severe asthma, in which oxygen is administered only to patients with hypoxemia and at a concentration sufficient to correct oxygen deficiency without inducing hyperoxemia [105]

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CD4 + T cells from RA patients demonstrate decreased expression of the glycolytic rate-limiting enzyme PFKFB3 compared with healthy donor PBMCs, resulting in diminished pyruvate and ATP production (149)

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