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The intervention modulated the structure of obesity-associated gut microbiota, enriching beneficial taxa such as Bifidobacterium and Lactobacillus , and elevated levels of microbial metabolites, notably butyrate

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Identified cellular targets through which PKA activation produces a bronchodilator effect include: MLCK: Phosphorylation of myosin light chain kinase (MLCK) by cAMP-dependent protein kinase (PKA) decreases the affinity of the kinase for Ca2+ and calmodulin , resulting in a decrease in MLCK activity

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