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Individuals with gastrointestinal disorders such as Crohns disease or celiac disease are likely to suffer from impaired B12 absorption

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124 However, correlative changes in parameters that may be associated with but are not specific to ferroptosis do not prove that the mode of cell death is ferroptosis

Hypoxia stimulates the release of a large amount of ATP into the TME, and high concentrations of ATP regulate Ca 2+ signaling through P2Y11, which is specifically expressed in cancer cells, and enhance the migration ability of HCC cells (151, 152)