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When APAP is taken in small doses, most drugs are cleared by sulfation and glucuronidation, and only a tiny amount of drugs can be metabolized by cytochrome P450 enzymes to produce N-acetyl-1,4-benzoquinone imine (NAPQI), which is detoxified by binding to GSH in the liver (van Rongen et al., 2016)

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Interestingly, lowering the temperature to 10 C which inhibits carrier-mediated transport and allows only passive diffusion [62, 63] led to substantial decrease in uptake of CIPp-18