Inhibition of the Trx system by auranofin induced cell death (most likely ferroptosis) only in non-endocrine small cell lung cancer, whereas inhibition of the Grx system by buthionine sulfoximine killed specifically the endocrine cells [203]
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The synthesis of CRP is mainly controlled by IL-6 but IL-1 and TNF- may influence CRP levels as well and increase of CRP in blood and other body fluids is a constant result of these proinlammatory cytokines [15,16]
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