Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
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SCHEME 1 The final compounds -L-H-Glu(L-Glu-OH)OH 2 (( S , S ) 4-amino-4-carboxybutanoyl) glutamic acid) as chlorhydrate salt were obtained in 90% yield by removing N -BOC and tert butyl esters protecting groups in acidic conditions using HCl 4N aqueous solution in dioxane (Scheme 2)
Several studies point to the importance of BDNF in pathways of adult neurogenesis [163], suggesting it might contribute to the effect of nutrients on among others the adult neurogenic process
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