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The debilitating fatigue which seems to be the most common symtpom of B12 deficiency may be due to a combination of neurological factors, anaemia, and the role of B12 in the mitochondria

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Severely damaged red neurons, without any inflammatory reaction, were present in all animals, in more then one half of hippocampal neurons, neurons of the dentate nucleus, Purkinje cells and other cerebellar nuclei

At present, the functions of these enzymes in plants are not addressed

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