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Description

The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework

Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively

This is because B12 is not a standard medication in the US or UK, so it is often made in small-scale compounding pharmacies rather than in large-scale manufacturing facilities