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Consistent with preclinical findings, treatment with a DPP1 inhibitor in a phase 2 study reduced NSP activity and improved outcomes in patients with bronchiectasis

Nevertheless, evidence across metabolomic datasets remains mixed and requires further confirmation

doi: 10.1007/s10787-022-00945-9 197 BalaAMondalCHaldarPKKhandelwalB

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Moreover, their results also supported the notion that AGE production may be prevented or even diminished by antioxidant supplementation with vitamin B derivatives [305, 306], and/or vitamins A, C, and E [307]