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Peer review Peer review information Nature Communications thanks Matteo Villa, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

investigated for selective fat-mobilising effects independent of GH receptor signalling Cartilage & joint research Examined in chondrocyte models and osteoarthritis frameworks for anabolic effects on cartilage matrix synthesis Metabolic profile Investigated for absence of the hyperglycaemic and IGF-1-elevating effects associated with full-length hGH, making it a useful tool compound for isolating GHs metabolic effects Body composition models Studied in rodent obesity models for changes in fat mass, lean mass, and energy expenditure Clinical research history Progressed to early-phase human trials in Australia (2000s) for obesity and osteoarthritis indications

Subsequent wells contained drug concentrations that were serially diluted by half, from the first well to the last

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The same applies to different ethnic groups: Japanese eyes are reported to have an increase in iris pigmentation of approximately 50%, higher than reported for people of European descent (LatanoprostInduced Iris Pigmentation Study Group, 2006)