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In this text-mining study, the AD-pathway_score (ranging from 1 to 5) reflects the strength of the relevance of a given pathway to AD, based on a curated review of the specific pathway-associated literature (lower scores indicate stronger associations)

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This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression

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