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In the group that received oral administration of the fingerroot extract for 7 days, the amount of unchanged panduratin A excreted via the feces was most significantly increased (60% of the administered dose), and no difference in the amount excreted in the urine was observed (11% of the administered dose), as shown in Table 3

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in fact, these treatments promoted UPR mt and mitophagy, restoring mitochondrial and organismal function, and even stimulated the reduction of amyloid deposits in these models 114

This big increase calls for more research into why this happens