It is often associated with multiple genetic polymorphisms including filaggrin mutations, variations in N -acetyltransferases (NATs), glutathione S -transferases (GSTs), cytokine genes (e.g., TNF-, IL-16), and various immune enzymes [9, 38, 39]
This finding was consistent for cardiovascular mortality (HR 0.90, 95% CI from 0.50 to 1.61) and all-cause mortality (HR 0.80, 95% CI from 0.51 to 1.25)
Researchers know that people who have less methylfolate available because of the MTHFR gene mutation have a higher risk of heart attack and stroke
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