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Polyphenols are also subject to various denaturing conditions (103), such as heat, light, oxygen, pH variations, and enzymatic degradation, which reduce their bioavailability and limit their efficacy as bioactive compounds (108)

To determine whether this was specific for KIN-19, we tested the other 18 kinases that were previously screened against the primed S114 and found only KIN-19 as a significant predicted interaction

While evaluating therapeutic efficacy was not the primary endpoint of the Phase I trial due to its small sample size, clinical outcomes for different doses of dental pulp stem cells are shown in Supplementary Table 12