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These cardiac repair studies established TB-500 as one of the most extensively characterised peptide research tools for studying cardiac regeneration biology and provided the foundational evidence for thymosin beta-4s role as an endogenous cardiac repair mediator and establishing that actin-sequestering peptides have biological significance beyond cytoskeletal regulation in the context of cardiac injury response

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Further studies to enrichment analysis of identified DEGs were performed to recognize biological functions and signaling pathways

Jellin JM, Batz F, Hitchens K