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Oxidative stress, mitochondrial dysfunction, and neuroinflammation play key roles in PD progression

It is known that cellular senescence and also the aging process are associated with epigenetic remodeling of the chromatin landscape

Targeted delivery of IGF-I to spinal cord motor neurons via intramuscular injection of IGF-I, fused to non-toxic tetanus toxin fragment-C (TTC), promoted maintenance of muscle fiber innervation and prevented neuromuscular junction atrophy and fragmentation in aged muscle fibers[32]

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Board-certified in family medicine with experience in hospital medicine, he brings over two decades of clinical experience to reviewing research content and ensuring scientific accuracy