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(Contraindications) Sermorelin is contraindicated in individuals with: Known allergy to Sermorelin acetate or its components.19 Pregnancy (Category C 13) or breastfeeding.7 Active malignancy (cancer), due to GH's cell proliferation potential.6 Untreated hypothyroidism, as it can blunt Sermorelin's effects.6 Acute critical illness.39 Certain pituitary conditions (e.g., GHD secondary to intracranial lesions were not studied in some key trials 13)

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For instance, gonadorelin replicates endogenous GnRH to promote luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that support Leydig and Sertoli cell function and spermatogenesis, respectively