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In contrast, studies using CBMCs, collected prior to RDS development, did not reveal differences in GR number estimated by ligand-binding assays (238) or real-time PCR (239, 240) between RDS neonates and gestational age-matched controls

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[] To overcome these complications, the calcium salt of disodium edetate (CaNa 2 EDTA) became the next chelator developed for clinical use

Under physiological conditions, the BBB serves as a critical interface composed of endothelial cells connected by tight junction proteins, pericytes, and surrounding glial elements regulating the transport of molecules to the central nervous system

& Yorek, M