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Exposure to EC aerosols enhanced susceptibility to infection, as shown by increased inflammatory responses in Porphyromonas gingivalis- and Fusobacterium nucleatum- challenged epithelial and malignant cell lines, highlighting a dysbiotic microbiome and immune dysregulation in EC users [61]

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When it premiered in 2015, Juul incorporated innovations in aesthetic design, electronics and chemistry that were big departures from earlier e-cigarettes