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CD4+ T cells recognize antigens bound to MHC class II molecules, and, as noted, class II molecules are expressed on APCs that possess the capability of antigen capture through phagocytosis or binding to surface antibody [67, 68]

Interestingly, the presentation of DAPT and BMS appeared to exert the opposite action to TB-500, suggesting that the Notch/NF-B pathways may mediate TB-500s proposed action on angiogenesis

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We observed the dissociation of p53 TAD (13-61) from FOXO4 FHD upon the addition of p53 TAD PEP, resulting in a chemical shift of the 15 N-p53 TAD-FOXO4 FHD complex towards the unbound state of p53 TAD (Figure