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doi: 10.1152/ajpheart.01042.2003

As one of the first systems in the body to respond to outside threats, your nose, mouth, throat, and lungs constantly respond to large numbers of free radicals from increased oxygen presence, infectious diseases, and toxic environmental exposures such as dust, smog, and smoke

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In the following sections, we delineate the mechanisms and regulatory dimensions governing these astrocytic state transitions and their contributions to reactive diversity under environmental stressors and pathological challenges