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Deficiency may cause fatigue, neurological symptoms, and cognitive changes, with treatment often improving symptoms when deficiency is present

MOTS-c Before You Start: The Critical Protocol Facts MOTS-c is a mitochondria-derived peptide that regulates cellular energy metabolism, making it mechanistically distinct from every other peptide in clinical use today

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Research has confirmed that inhibiting polyamine biosynthesis with the ornithine decarboxylase inhibitor -difluoromethylornithine significantly mitigates increased BBB permeability, Evans blue extravasation, and brain tissue water content in models of cerebral ischemia (102)