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Yes, combining an intranasal corticosteroid spray with an oral antihistamine is a recognised approach when symptoms are not fully controlled by one treatment alone, and is consistent with NICE CKS guidance on allergic rhinitis

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To avoid randomized non-starters and potential bias due to differential early attrition from prior knowledge of group assignment, randomization will occur at the time of visit 0 when participants first receive tobacco products specific to their assigned condition, and neither the research assistant nor participant will know the assignment in advance