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Desialylation of IGF-1R by neuraminidase I causes quenching of proliferative response in L6 myoblasts 30
You dont need to dose every few hours
No published time-course demonstrates diminishing effect, and mechanistic reviews note the absence of receptor desensitization that would predict tolerance
I use some folded loo roll over the top of the ampoule, just in case it breaks (only one break in 2 years of injecting 23 times per week)
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