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Uric acid, a potent antioxidant and the terminal product of purine metabolism is decreased in serum of GWS (Naviaux et al., 2019)

These agents can more specifically block PR-related signaling pathways, potentially yielding superior therapeutic responses

If fatigue persists or worsens over time, checking B12 levels, thyroid function, and other nutritional markers is warranted

Ideally, answers to such questions will help paint a clearer picture of the role of this interesting enzyme in immune function and immunopathology, and might someday allow physicians to harness immunometabolic diagnostic and therapeutic tools to improve outcomes in severe sepsis and various immune disorders

479,480 These advancements offer promising avenues for managing genitourinary complications in DN