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However, generally excreted does not mean entirely without consequence. Emerging research has raised questions about whether chronically elevated serum B12 levels may serve as a marker for underlying conditions or could be associated with certain health concerns

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Vitamin B12 (Cyanocobalamin): Helps support red blood cell formation and healthy nerve cells

Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)