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Some patients experience new psychotic or manic episodes, particularly those with a history of bipolar disorder or depression

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FUNDING This work was supported by grant R56DA055996 and cooperative agreement U54DA036151 (Yale Tobacco Center of Regulatory Science) to SEJ from the National Institute on Drug Abuse and by the United States Food and Drug Administration Center for Tobacco Products

After she has completed her instruction, White Buffalo Calf Woman leaves the village, transforms herself into a black, then red, then brown, then white buffalo, and finally vanishes over a distant hill