Methods Animal studies All animal studies were performed according to protocols approved by the University Committee on Animal Resources at the University of Rochester Medical Center
This was indicative of a shift in redox state due to EGT absence, particularly following exposure to 3 mM H 2 O 2
As with other glutathione peroxidases, GPx1 has a conserved catalytic tetrad composed of Sec or Cys, Gln, Trp, and Asn, where the Sec is surrounded by four arginines (R 57, 103, 184, 185
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