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10.1016/j.neuropharm.2013.11.004 Neuropharmacology 132 SelvakumarG

This phenomenon is often exploited in cancer treatments, where therapies aim to increase ROS levels beyond a threshold that cancer cells can tolerate, effectively inducing their death while sparing normal cells [9]

Indeed, oxidized Hb binds to the cytoplasmic domain of band 3 protein in the RBC membrane (Figure 2), triggering band 3 clustering, marking the erythrocyte for removal by splenic macrophages [23, 25]