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Parkin ubiquitinates mitochondrial surface proteins, marking them for degradation via the autophagosome ( Therefore, suppressing the formation of autophagosomes can help mitigate damage caused by autophagy, decrease the activation of digestive enzymes, and provide some relief from AP ( 3.6 Mitochondrial regulation of cell death (apoptosis, necrosis and pyroptosis) Besides supplying energy to cells, mitochondria regulate necrosis and apoptosis of acinar cells through changes in mitochondrial membrane permeability (MMP) ( 2+ accumulation in acinar cells triggers the opening of the MPTP in the IMM, leading to loss of mitochondrial membrane potential, impaired ATP production, and eventual necrosis (see Figure 2 )