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Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

bound to TC Excessive vitamin B 12 in the circulation, e.g., such as after injections, usually exceeds the binding capacity of TC and is excreted in the urine

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This happens due to a lack of an intrinsic factor, a protein necessary for B12 absorption in the stomach