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Gastrointestinal parameters After oral Tac intake, it undergoes presystemic metabolism, which mainly involves CYP3A4 and CYP3A5 metabolism in gut and liver as well as P-gp transport into the intestinal lumen ( Because of several gastrointestinal parameters, absorption and bioavailability of Tac (when administered orally) are highly variable ( Tac bioavailability is generally influenced by food intake

We found that, for SNP rs179982 (gene CPT2 ), patients with GG genotype had lower plasma L-Cn levels than those with AA genotype ( Figure 5A )

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Huang H-C, Nguyen T, Pickett CB