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BPC-157 is a documented exception: it is acid-stable because it evolved as a native component of human gastric juice, where it performs its protective functions at physiological concentrations

[1] Other rare side effects noted (mostly in older literature or high-dose use) include: polycythemia vera and peripheral vascular thrombosis in patients receiving repeated injections (though these associations are not well understood, they were listed in prior product literature as possible adverse events)

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1000 g/L) and suggested oxidative stress at the transcriptional level, as evidenced by down-regulation of the antioxidant sod1 (superoxide dismutase 1) and cyp1a (cytochrome P450 family 1 subfamily A) genes

However, experts in the area generally concur that a combination of data from multiple endpoints is needed to discriminate sensitizing and/or irritant substances in vitro