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Target Organs of Metals Released from Metal-on-Polyethylene Knee and Hip Arthroplasty Implants: Implications for Tissue Metal Profiles

This sustained release helps maintain more consistent levels of glutathione in the body, offering prolonged antioxidant support compared to non-liposomal forms

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10.1128/MCB.01275-12 77 KishorA.WhiteE

Iron metabolism plays a central role, as excessive intracellular iron promotes the Fenton reaction, generating lethal amounts of ROS that drive lipid peroxidation [5]