Clinical Findings of Target Organ Damage Target Organ Damage Hypertensive encephalopathy Intracranial hemorrhage Unstable angina Acute myocardial infarction Acute left ventricular failure with pulmonary edema Dissecting aortic aneurysm Eclampsia Clinical Findings Funduscopic: papilledema, hemorrhage, exudates Neurologic: somnolence, confusion, seizures, coma, visual deficits or blindness Cardiac: S4 gallop, ischemic changes on ECG, chest x-ray consistent with pulmonary edema, chest pain Renal: oliguria, progressive azotemia, hematuria, proteinuria Other: dyspnea Reprinted with permission from JNC-VII.
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Ultimately, NAC produced the same effect, as it induced a shift in redox status that limits the ability of animals to stay awake