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"MOTS-c levels in human blood decline with age and correlate with insulin sensitivity, positioning the peptide not just as a metabolic tool but as a potential biomarker of mitochondrial vitality." On the exercise side, a pivotal finding came from studies measuring endogenous MOTS-c in human subjects

Researchers took a closer look at the results after the main study was completed, and these findings were shared at a major medical conference (the EASD congress) in September 2025

While weve known for a long time that mood shifts and depression can increase during midlife, the conversation is expanding

The development of senolytic drugs demonstrated that targeting these cells limits the deterioration of patients condition, by inducing apoptosis

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